In Silico Study of Avocado (Persea americana Mill.) Seed Compounds Against PBP2a Receptor on Staphylococcus aureus

  • Meike Tyas Kusuma Department of Biology, Faculty of Science and Technology, State Islamic University of Maulana Malik Ibrahim Malang, Indonesia
  • Retno Susilowati Department of Biology, Faculty of Science and Technology, State Islamic University of Maulana Malik Ibrahim Malang, Indonesia

Abstract

The nosocomial infection causes 1,4 million mortality every day in the world. International Nosocomial Infection Control Consortium (INICC) data shows that 84,4% nosocomial infection is caused by S. aureus that can cause skin infection. Avocado (P. americana) seed has been reported as an antibacterial agent and used for dermatological applications. This research was aimed to know the potential of antibacterial activity of ethanolic extract of avocado seed in silico study. The in silico test used molecular docking method with PyRx software between PBP2a as receptor and phytochemical compounds in avocado seed as a ligand. The result showed that rutin compound had the best potential to bind PBP2a (binding affinity: -18,2 kcal/mol). Thus, phytochemical active compounds in avocado seed can be recommended as an antibacterial drug and can increase the number of fibroblast cells caused by S. aureus.

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Published
2018-10-02
How to Cite
KUSUMA, Meike Tyas; SUSILOWATI, Retno. In Silico Study of Avocado (Persea americana Mill.) Seed Compounds Against PBP2a Receptor on Staphylococcus aureus. Bioinformatics and Biomedical Research Journal, [S.l.], v. 1, n. 2, p. 45-48, oct. 2018. ISSN 2620-3324. Available at: <http://www.bbrjournal.com/index.php/bbrj/article/view/23>. Date accessed: 15 dec. 2018.
Keywords: In silico, avocado seed, PBP2a, Staphylococcus aureus